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Editor's Choice
Unraveling Epilepsy: Investigating stem cell approaches for innovative treatment and future cure
1
Department of Molecular Biology and Genetics, Faculty of Engineering and Natural Sciences, Uskudar University, 34662,
Uskudar, Istanbul, Türkiye
2
Department of Molecular Biology, Institute of Science, Uskudar University, 34662, Uskudar, Istanbul, Türkiye
3
Uskudar University, Stem Cell Research and Application Center (USKOKMER), 34662, Uskudar, Istanbul, Türkiye
Submission date: 2024-08-09
Final revision date: 2024-08-30
Acceptance date: 2024-09-09
Online publication date: 2024-10-15
Corresponding author
Sevim Isik
Uskudar University, Stem Cell Research and Application Center (USKOKMER), 34662, Uskudar, Istanbul, Türkiye
Uskudar University, Stem Cell Research and Application Center (USKOKMER), 34662, Uskudar, Istanbul, Türkiye
HIGHLIGHTS
- Epilepsy is a persistent neurological disorder
- The management of epilepsy remains a significant challenge
- Stem cell therapies have become a hopeful approach
- This review investigates the present state of stem cell therapies in epilepsy
KEYWORDS
TOPICS
ABSTRACT
Epilepsy is a persistent neurological disorder characterized by repeated, spontaneous seizures that arise without a specific cause. These seizures result from abnormal electrical activity in the brain, leading to a range of symptoms, from brief periods of unconsciousness or minor sensory disturbances to severe convulsions. The management of epilepsy remains a significant challenge, as current treatment modalities, primarily involving antiepileptic drugs and surgical interventions to remove seizure foci, often provide adequate control for a substantial portion of patients. For this reason, stem cell therapies have become a hopeful approach because of their ability to potentially restore and renew impaired neural networks, which is particularly relevant for neurological disorders like epilepsy. This review investigates the present state of stem cell therapies in epilepsy, analyzing distinct types of stem cells, their mode of action, preclinical and clinical trials, as well as future research prospects.
ACKNOWLEDGEMENTS
Not applicable.
FUNDING
Not applicable.
CONFLICT OF INTEREST
The authors declare no conflict of interest.
PEER REVIEW INFORMATION
Article has been screened for originality
Externally peer reviewed.
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